|
Symbol Name ID |
Ptgs2
prostaglandin-endoperoxide synthase 2 MGI:97798 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating antibody level |
Eosinophilia |
Increased T cell count |
Leukopenia |
Sinusitis |
Chronic sinusitis |
Keratoconjunctivitis sicca |
Abnormal lymph node morphology |
Lymphadenopathy |
Hepatosplenomegaly |
Peritoneal abscess |
Subacute progressive viral hepatitis |
Pancreatitis |
Uveitis |
Erythema nodosum |
Maculopapular exanthema |
Recurrent pneumonia |
Anti-citrullinated protein antibody positivity |
Rheumatoid factor positive |
Asthma |
Nontuberculous mycobacterial pulmonary infection |
Recurrent Burkholderia cepacia infections |
Recurrent Haemophilus influenzae infections |
Recurrent Staphylococcus aureus infections |
Recurrent Aspergillus infections |
Recurrent respiratory infections |
Recurrent bronchopulmonary infections |
Recurrent lower respiratory tract infections |
| Disease(s) Associated with PTGS2 | ||||||||||||||||||||||||||||
| asthma | ||||||||||||||||||||||||||||
| cystic fibrosis | ||||||||||||||||||||||||||||
| hepatocellular carcinoma | ||||||||||||||||||||||||||||
| idiopathic pulmonary fibrosis | ||||||||||||||||||||||||||||
| pancreatic cancer | ||||||||||||||||||||||||||||
| rheumatoid arthritis | ||||||||||||||||||||||||||||
| sarcoidosis |
| Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
increased susceptibility to induced colitis |
peritoneal inflammation |
enlarged spleen |
spleen hyperplasia |
abnormal class switch recombination |
abnormal memory B cell differentiation |
increased leukocyte cell number |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG3 level |
increased IgM level |
abnormal macrophage physiology |
abnormal mesenteric lymph node morphology |
increased tumor necrosis factor secretion |
decreased susceptibility to induced arthritis |
decreased susceptibility to endotoxin shock |
increased susceptibility to endotoxin shock |
kidney inflammation |
pyelonephritis |
tubulointerstitial nephritis |
abnormal response to infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||
| Ptgs2tm1.1Fun/Ptgs2tm1.1Fun | ||||||||||||||||||||||||
| Ptgs2tm1.1Wls/Ptgs2tm1.1Wls | ||||||||||||||||||||||||
| Ptgs2tm1Jed/Ptgs2tm1Jed | * | |||||||||||||||||||||||
| Ptgs2tm1Unc/Ptgs2tm1Unc | * | |||||||||||||||||||||||
| Ptgs2tm1Unc/Ptgs2+ | ||||||||||||||||||||||||
| Ptgs2tm1Unc/Ptgs2tm2.1Hahe | ||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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